Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish-Reference-Cited by-同舟云学术

Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish

Published:2016-11-04 Issue:6312 Volume:354 Page:630-634
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Mokalled Mayssa H.¹,Patra Chinmoy²,Dickson Amy L.¹,Endo Toyokazu¹,Stainier Didier Y. R.²,Poss Kenneth D.¹

Affiliation:

1. Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.

2. Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.

Abstract

Spinal cord regeneration in zebrafish Unlike humans, zebrafish can regenerate their spinal cord. Mokalled et al. identified a growth factor in zebrafish that helps this process (see the Perspective by Williams and He). The protein encoded by ctgfa ( connective tissue growth factor a ) is secreted after injury and encourages glial cells to form a bridge across the spinal lesion. Addition of this protein improved spinal cord repair in injured zebrafish. Science , this issue p. 630 ; see also p. 544

Funder

NIH

Max Planck Society

Duke University School of Medicine

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference26 articles.

1. Axonal regrowth after spinal cord transection in adult zebrafish

2. Cellular response after crush injury in adult zebrafish spinal cord

3. Fgf-Dependent Glial Cell Bridges Facilitate Spinal Cord Regeneration in Zebrafish