The nature of nurture: Effects of parental genotypes-Reference-Cited by-同舟云学术

The nature of nurture: Effects of parental genotypes

Published:2018-01-26 Issue:6374 Volume:359 Page:424-428
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kong Augustine¹²³^ORCID,Thorleifsson Gudmar¹^ORCID,Frigge Michael L.¹^ORCID,Vilhjalmsson Bjarni J.⁴⁵^ORCID,Young Alexander I.¹²⁶,Thorgeirsson Thorgeir E.¹^ORCID,Benonisdottir Stefania¹^ORCID,Oddsson Asmundur¹^ORCID,Halldorsson Bjarni V.¹^ORCID,Masson Gisli¹^ORCID,Gudbjartsson Daniel F.¹³^ORCID,Helgason Agnar¹⁷^ORCID,Bjornsdottir Gyda¹^ORCID,Thorsteinsdottir Unnur¹⁸^ORCID,Stefansson Kari¹⁸^ORCID

Affiliation:

1. deCODE genetics/Amgen, 101 Reykjavik, Iceland.

2. Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, UK.

3. School of Engineering and Natural Sciences, University of Iceland, 101 Reykjavik, Iceland.

4. Bioinformatics Research Centre, Aarhus University, 8000 Aarhus, Denmark.

5. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

6. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

7. Department of Anthropology, University of Iceland, 101 Reykjavik, Iceland.

8. Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.

Abstract

Genetic variants provide a nurturing environment Genetic variants in parents may affect the fitness of their offspring, even if the child does not carry the allele. This indirect effect is referred to as “genetic nurture.” Kong et al. used data from genome-wide association studies of educational attainment to construct polygenic scores for parents that only considered the nontransmitted alleles (see the Perspective by Koellinger and Harden). The findings suggest that genetic nurture is ultimately due to genetic variation in the population and is mediated by the environment that parents create for their children. Science , this issue p. 424 ; see also p. 386

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference42 articles.

1. Selection in Reference to Biological Groups I. Individual and Group Selection Applied to Populations of Unordered Groups

2. M. Lynch B. Walsh Genetics and Analysis of Quantitative Traits (Sinauer Associates 1998).

3. Assessing the Causal Relationship of Maternal Height on Birth Size and Gestational Age at Birth: A Mendelian Randomization Analysis

4. Using Genetic Variation to Explore the Causal Effect of Maternal Pregnancy Adiposity on Future Offspring Adiposity: A Mendelian Randomisation Study

5. Parental involvement in middle school: A meta-analytic assessment of the strategies that promote achievement.

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