Use of CD134 As a Primary Receptor by the Feline Immunodeficiency Virus-Reference-Cited by-同舟云学术

Use of CD134 As a Primary Receptor by the Feline Immunodeficiency Virus

Published:2004-02-20 Issue:5661 Volume:303 Page:1192-1195
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Shimojima Masayuki¹²³⁴⁵,Miyazawa Takayuki¹²³⁴⁵,Ikeda Yasuhiro¹²³⁴⁵,McMonagle Elizabeth L.¹²³⁴⁵,Haining Hayley¹²³⁴⁵,Akashi Hiroomi¹²³⁴⁵,Takeuchi Yasuhiro¹²³⁴⁵,Hosie Margaret J.¹²³⁴⁵,Willett Brian J.¹²³⁴⁵

Affiliation:

1. Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

2. Department of Veterinary Public Health, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan.

3. Host and Defense, PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan.

4. Department of Immunology and Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, London W1T 4JF, UK.

5. Retrovirus Research Laboratory, Institute of Comparative Medicine, University of Glasgow, Glasgow G61 1QH, UK.

Abstract

Feline immunodeficiency virus (FIV) induces a disease similar to acquired immunodeficiency syndrome (AIDS) in cats, yet in contrast to human immunodeficiency virus (HIV), CD4 is not the viral receptor. We identified a primary receptor for FIV as CD134 (OX40), a T cell activation antigen and costimulatory molecule. CD134 expression promotes viral binding and renders cells permissive for viral entry, productive infection, and syncytium formation. Infection is CXCR4-dependent, analogous to infection with X4 strains of HIV. Thus, despite the evolutionary divergence of the feline and human lentiviruses, both viruses use receptors that target the virus to a subset of cells that are pivotal to the acquired immune response.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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