Suppression of MicroRNA-Silencing Pathway by HIV-1 During Virus Replication-Reference-Cited by-同舟云学术

Suppression of MicroRNA-Silencing Pathway by HIV-1 During Virus Replication

Published:2007-03-16 Issue:5818 Volume:315 Page:1579-1582
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Triboulet Robinson¹²³⁴⁵,Mari Bernard¹²³⁴⁵,Lin Yea-Lih¹²³⁴⁵,Chable-Bessia Christine¹²³⁴⁵,Bennasser Yamina¹²³⁴⁵,Lebrigand Kevin¹²³⁴⁵,Cardinaud Bruno¹²³⁴⁵,Maurin Thomas¹²³⁴⁵,Barbry Pascal¹²³⁴⁵,Baillat Vincent¹²³⁴⁵,Reynes Jacques¹²³⁴⁵,Corbeau Pierre¹²³⁴⁵,Jeang Kuan-Teh¹²³⁴⁵,Benkirane Monsef¹²³⁴⁵

Affiliation:

1. Laboratoire de Virologie Moléculaire, Institut de Génétique Humaine, Montpellier, France.

2. Laboratoire des Lentivirus et Transfert de Gènes, Institut de Génétique Humaine, Montpellier, France.

3. Institut de Pharmacologie Moléculaire et Cellulaire, UMR6097 CNRS/UNSA, Sophia Antipolis, France.

4. Service des Maladies Infectieuses et Tropicales, Hôpital Gui de Chauliac, Montpellier, France.

5. Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Abstract

MicroRNAs (miRNAs) are single-stranded noncoding RNAs of 19 to 25 nucleotides that function as gene regulators and as a host cell defense against both RNA and DNA viruses. We provide evidence for a physiological role of the miRNA-silencing machinery in controlling HIV-1 replication. Type III RNAses Dicer and Drosha, responsible for miRNA processing, inhibited virus replication both in peripheral blood mononuclear cells from HIV-1–infected donors and in latently infected cells. In turn, HIV-1 actively suppressed the expression of the polycistronic miRNA cluster miR-17/92. This suppression was found to be required for efficient viral replication and was dependent on the histone acetyltransferase Tat cofactor PCAF. Our results highlight the involvement of the miRNA-silencing pathway in HIV-1 replication and latency.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference26 articles.

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2. Suppressors of RNA silencing encoded by plant viruses and their role in viral infections

3. Anti-viral RNA silencing: do we look like plants ?

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5. CD8+Cell Anti-HIV Activity: Nonlytic Suppression of Virus Replication

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