Long-Term Memory Requires PolyADP-ribosylation-Reference-Cited by-同舟云学术

Long-Term Memory Requires PolyADP-ribosylation

Published:2004-06-18 Issue:5678 Volume:304 Page:1820-1822
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Cohen-Armon Malka¹²³,Visochek Leonid¹²³,Katzoff Ayelet¹²³,Levitan David¹²³,Susswein Abraham J.¹²³,Klein Rodika¹²³,Valbrun Mireille¹²³,Schwartz James H.¹²³

Affiliation:

1. The Neufeld Cardiac Research Institute, Sheba Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel.

2. Faculty of Life Sciences, Gonda [Goldschmied] Medical Diagnostic Research Center, Bar-Ilan University, Ramat-Gan 52900, Israel.

3. Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.

Abstract

PolyADP-ribose-polymerase 1 is activated in neurons that mediate several forms of long-term memory in Aplysia . Because polyADP-ribosylation of nuclear proteins is a response to DNA damage in virtually all eukaryotic cells, it is surprising that activation of the polymerase occurs during learning and is required for long-term memory. We suggest that fast and transient decondensation of chromatin structure by polyADP-ribosylation enables the transcription needed to form long-term memory without strand breaks in DNA.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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