Single-trial spike trains in parietal cortex reveal discrete steps during decision-making-Reference-Cited by-同舟云学术

Single-trial spike trains in parietal cortex reveal discrete steps during decision-making

Published:2015-07-10 Issue:6244 Volume:349 Page:184-187
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Latimer Kenneth W.¹²,Yates Jacob L.¹²,Meister Miriam L. R.²³,Huk Alexander C.¹²⁴⁵,Pillow Jonathan W.¹²⁵⁶

Affiliation:

1. Center for Perceptual Systems, The University of Texas at Austin, Austin, TX 78712, USA.

2. Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA.

3. Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA.

4. Department of Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA.

5. Department of Psychology, The University of Texas at Austin, Austin, TX 78712, USA.

6. Princeton Neuroscience Institute and Department of Psychology, Princeton University, Princeton, NJ 08544, USA.

Abstract

A better way to explain neuronal activity A brain region called the lateral intraparietal (LIP) area is involved in primate decision-making. The dominant model to explain neuronal firing in LIP assumes that neurons slowly accumulate sensory evidence in favor of one choice or another. Latimer et al. hypothesized that neurons instead exhibit rapid steps or jumps in their firing rate, reflecting discrete changes in the animal's decision state. They recorded from LIP neurons in macaque monkeys performing a motion-discrimination task. LIP spike trains in most cells involved discrete stepping dynamics rather than slow evidence integration dynamics. Science , this issue p. 184

Funder

National Science Foundation

National Institutes of Health

National Institute of Mental Health

National Institute on Drug Abuse

National Eye Institute

McKnight Foundation

Sloan Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary