The cryo-EM structure of a ribosome–Ski2-Ski3-Ski8 helicase complex-Reference-Cited by-同舟云学术

The cryo-EM structure of a ribosome–Ski2-Ski3-Ski8 helicase complex

Published:2016-12-16 Issue:6318 Volume:354 Page:1431-1433
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Schmidt Christian¹,Kowalinski Eva²,Shanmuganathan Vivekanandan¹,Defenouillère Quentin³⁴,Braunger Katharina¹,Heuer André¹,Pech Markus¹,Namane Abdelkader³,Berninghausen Otto¹,Fromont-Racine Micheline³,Jacquier Alain³,Conti Elena²,Becker Thomas¹,Beckmann Roland¹

Affiliation:

1. Gene Center and Center for Integrated Protein Science Munich, Department of Biochemistry, Feodor-Lynen-Strasse 25, University of Munich, 81377 Munich, Germany.

2. Max Planck Institute of Biochemistry, Department of Structural Cell Biology, Am Klopferspitz 18, 82152 Martinsried, Munich, Germany.

3. Institut Pasteur, Génétique des Interactions Macromoléculaires, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 3525, Rue du Docteur Roux 25-28, 75724 Paris, France.

4. Sorbonne Universités, UPMC Paris 6, Complexité du Vivant, 75252 Paris Cedex 05, France.

Abstract

Getting rid of faulty mRNA The cell monitors the health of its mRNAs, destroying those that are faulty or damaged. Destruction by the exosome complex prevents them from being used to synthesize deranged and potentially dangerous proteins. Schmidt et al. determined the structure of the Ski helicase complex, which guides RNAs to the exosome complex destruction machinery in association with a mRNAbound ribosome. The end of the mRNA is threaded from the ribosome into the heart of the helicase, whence the message would be channeled into the maw of the exosome complex. Science , this issue p. 1431

Funder

German Research Council

Max Planck Gesellschaft

Agence Nationale de la Recherche

Center for Integrated Protein Science Munich (CiPS-M)

Graduate School of Quantitative Biosciences Munich (QBM)

European Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference47 articles.