Organizing Principles for a Diversity of GABAergic Interneurons and Synapses in the Neocortex-Reference-Cited by-同舟云学术

Organizing Principles for a Diversity of GABAergic Interneurons and Synapses in the Neocortex

Published:2000-01-14 Issue:5451 Volume:287 Page:273-278
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Gupta Anirudh¹,Wang Yun¹,Markram Henry¹

Affiliation:

1. Department of Neurobiology, The Weizmann Institute for Science, 76100 Rehovot, Israel.

Abstract

A puzzling feature of the neocortex is the rich array of inhibitory interneurons. Multiple neuron recordings revealed numerous electrophysiological-anatomical subclasses of neocortical γ-aminobutyric acid–ergic (GABAergic) interneurons and three types of GABAergic synapses. The type of synapse used by each interneuron to influence its neighbors follows three functional organizing principles. These principles suggest that inhibitory synapses could shape the impact of different interneurons according to their specific spatiotemporal patterns of activity and that GABAergic interneuron and synapse diversity may enable combinatorial inhibitory effects in the neocortex.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference38 articles.

1. S. Ramón y Cajal Histology Due Système Nerveux de l'Homme et des Vertébrés L. Azoulay Transl. (Maloine Paris 1911) vol. 2.; E. White Cortical Circuits: Synaptic Organization of the Cerebral Cortex; Structure Function and Theory (Birkhauser Boston 1989).

2. Thomson A. M., Deuchars J., Cereb. Cortex 7, 510 (1997).

3. Kawaguchi Y., Kubota Y., Cereb. Cortex 7, 47 (1997);

4. DeFelipe J., Cereb. Cortex 3, 273 (1993);

5. Cauli B., et al., J. Neurosci. 17, 3894 (1997) .

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