Affiliation:
1. School of Biosciences, University of Exeter, Washington Singer Laboratories, Perry Road, Exeter EX4 4QG, UK.
Abstract
Rice blast is caused by the fungus
Magnaporthe grisea
, which elaborates specialized infection cells called appressoria to penetrate the tough outer cuticle of the rice plant
Oryza sativa
. We found that the formation of an appressorium required, sequentially, the completion of mitosis, nuclear migration, and death of the conidium (fungal spore) from which the infection originated. Genetic intervention during mitosis prevented both appressorium development and conidium death. Impairment of autophagy, by the targeted mutation of the
MgATG8
gene, arrested conidial cell death but rendered the fungus nonpathogenic. Thus, the initiation of rice blast requires autophagic cell death of the conidium.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
425 articles.
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