Phosphatidic Acid Is a pH Biosensor That Links Membrane Biogenesis to Metabolism-Reference-Cited by-同舟云学术

Phosphatidic Acid Is a pH Biosensor That Links Membrane Biogenesis to Metabolism

Published:2010-08-27 Issue:5995 Volume:329 Page:1085-1088
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Young Barry P.¹,Shin John J. H.¹,Orij Rick²,Chao Jesse T.¹,Li Shu Chen¹,Guan Xue Li³⁴,Khong Anthony⁵,Jan Eric⁵,Wenk Markus R.⁴⁶⁷,Prinz William A.⁸,Smits Gertien J.²,Loewen Christopher J. R.¹⁹

Affiliation:

1. Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada.

2. Department of Molecular Biology and Microbial Food Safety, University of Amsterdam, Amsterdam, 1018 WV, Netherlands.

3. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077.

4. Department of Biochemistry, University of Geneva, Sciences II, 30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland.

5. Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada.

6. Department of Biological Sciences National University of Singapore, Singapore 119077.

7. Swiss Tropical and Public Health Institute, University of Basel, Socinstrasse 57, P.O. Box 4002, Basel, Switzerland.

8. Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

9. The Brain Research Centre, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada.

Abstract

Intracellular pH and Lipid Metabolism Intracellular pH regulates metabolism by poorly understood mechanisms, but biosensors are likely to be important in this process. Young et al. (p. 1085 ) took a systems-biology approach in yeast to identify in excess of 200 genes that regulate phospholipid metabolism. They found that the signaling lipid, phosphatidic acid, appeared to act as a cytosolic biosensor via the pH-dependent binding of protein effectors to phosphatidic acid. This pH-dependent mechanism directly affects gene expression and is involved in a pathway in which nutrient availability regulates phospholipid metabolism to control production of membranes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference20 articles.

1. Protein Sensors for Membrane Sterols

2. Activation of a Membrane-Bound Transcription Factor by Regulated Ubiquitin/Proteasome-Dependent Processing

3. Phospholipid Metabolism Regulated by a Transcription Factor Sensing Phosphatidic Acid

4. Phosphatidic Acid Plays a Central Role in the Transcriptional Regulation of Glycerophospholipid Synthesis in Saccharomyces cerevisiae

5. The Where, When, and How of Organelle Acidification by the Yeast Vacuolar H + -ATPase

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