The maternal microbiota drives early postnatal innate immune development-Reference-Cited by-同舟云学术

The maternal microbiota drives early postnatal innate immune development

Published:2016-03-18 Issue:6279 Volume:351 Page:1296-1302
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Gomez de Agüero Mercedes¹,Ganal-Vonarburg Stephanie C.¹,Fuhrer Tobias²,Rupp Sandra¹,Uchimura Yasuhiro¹,Li Hai¹,Steinert Anna¹,Heikenwalder Mathias³,Hapfelmeier Siegfried⁴,Sauer Uwe²,McCoy Kathy D.¹,Macpherson Andrew J.¹

Affiliation:

1. Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, Murtenstrasse 35, University of Bern, 3010 Bern, Switzerland.

2. Institute of Molecular Systems Biology, Swiss Federal Institute of Technology (ETH) Zürich, 8093 Zürich, Switzerland.

3. Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.

4. Institute for Infectious Diseases, University of Bern, 3010 Bern, Switzerland.

Abstract

Mom's bugs shape of spring immunity In utero, babies are relatively microbe-free but are quickly colonized at birth. These early microbial residents help to shape our immune systems. Gomez de Agüero et al. wondered whether the maternal microbiome also affects the of springs' immune system during gestation. To do this, they transiently colonized otherwise microbe-free pregnant mice. Compared to those born to microbe-free moms, pups born to colonized moms had increased numbers of certain innate immune cells and different patterns of gene expression in their guts. Science , this issue p. 1296

Funder

Swiss National Science Foundation

European Research Council

Marie Curie Intra-European Fellowship

SNSF

ERC

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference53 articles.

1. Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict