Broad betacoronavirus neutralization by a stem helix–specific human antibody-Reference-Cited by-同舟云学术

Broad betacoronavirus neutralization by a stem helix–specific human antibody

Published:2021-09-03 Issue:6559 Volume:373 Page:1109-1116
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Pinto Dora¹,Sauer Maximilian M.²^ORCID,Czudnochowski Nadine³^ORCID,Low Jun Siong⁴^ORCID,Tortorici M. Alejandra²^ORCID,Housley Michael P.³,Noack Julia³^ORCID,Walls Alexandra C.²^ORCID,Bowen John E.²^ORCID,Guarino Barbara¹^ORCID,Rosen Laura E.³^ORCID,di Iulio Julia³^ORCID,Jerak Josipa⁴^ORCID,Kaiser Hannah³^ORCID,Islam Saiful³,Jaconi Stefano¹,Sprugasci Nicole¹^ORCID,Culap Katja¹^ORCID,Abdelnabi Rana⁵^ORCID,Foo Caroline⁵^ORCID,Coelmont Lotte⁵^ORCID,Bartha Istvan¹^ORCID,Bianchi Siro¹^ORCID,Silacci-Fregni Chiara¹,Bassi Jessica¹^ORCID,Marzi Roberta¹^ORCID,Vetti Eneida¹,Cassotta Antonino⁴^ORCID,Ceschi Alessandro⁶⁷⁸⁹^ORCID,Ferrari Paolo⁹¹⁰¹¹^ORCID,Cippà Pietro E.¹⁰¹²,Giannini Olivier⁹¹⁰^ORCID,Ceruti Samuele¹³^ORCID,Garzoni Christian¹⁴^ORCID,Riva Agostino¹⁵^ORCID,Benigni Fabio¹^ORCID,Cameroni Elisabetta¹,Piccoli Luca¹,Pizzuto Matteo S.¹,Smithey Megan³,Hong David³,Telenti Amalio³,Lempp Florian A.³,Neyts Johan⁵,Havenar-Daughton Colin³,Lanzavecchia Antonio¹,Sallusto Federica⁴¹⁶,Snell Gyorgy³,Virgin Herbert W.³¹⁷¹⁸,Beltramello Martina¹,Corti Davide¹,Veesler David²

Affiliation:

1. Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.

2. Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.

3. Vir Biotechnology, San Francisco, CA 94158, USA.

4. Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.

5. Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, 3000 Leuven, Belgium.

6. Clinical Trial Unit, Ente Ospedaliero Cantonale, 6900 Lugano, Switzerland.

7. Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Sciences of Southern Switzerland, Ente Ospedaliero Cantonale, 6900 Lugano, Switzerland.

8. Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, 8091 Zurich, Switzerland.

9. Faculty of Biomedical Sciences, Università della Svizzera italiana, 6900 Lugano, Switzerland.

10. Department of Medicine, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.

11. Clinical School, University of New South Wales, Sydney, NSW, 2052, Australia.

12. Faculty of Medicine, University of Zurich, 8057 Zurich, Switzerland.

13. Intensive Care Unit, Clinica Luganese Moncucco, 6900 Lugano, Switzerland.

14. Clinic of Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, 6900 Lugano, Switzerland.

15. III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, 20157 Milan, Italy.

16. Institute of Microbiology, ETH Zurich, 8093 Zurich, Switzerland.

17. UT Southwestern Medical Center, Dallas, TX 75390, USA.

18. Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

Targeting a range of betacoranaviruses In the past 20 years, three highly pathogenic β-coronaviruses have crossed from animals to humans, including the most recent: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A spike protein that decorates these viruses has an S1 domain that binds host cell receptors and an S2 domain that fuses the viral and cell membranes to allow cell entry. The S1 domain is the target of many neutralizing antibodies but is more genetically variable than S2, and antibodies can exert selective pressure, leading to resistant variants. Pinto et al . identified five monoclonal antibodies that interact with a helix in the S2 domain. The most broadly neutralizing antibody inhibited all β-coronavirus subgenera and reduced viral burden in hamsters infected with SARS-CoV-2. —VV

Funder

National Institutes of Health

U.S. Department of Energy

National Institute of General Medical Sciences

National Institute of Allergy and Infectious Diseases

GlaxoSmithKline foundation

Swiss National Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference86 articles.