Affiliation:
1. Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.
Abstract
Blueprint for a macromolecular machine
Nuclear pore complexes (NPCs) consist of around 1000 protein subunits, are embedded in the membrane that surrounds the nucleus, and regulate transport between the nucleus and the cytoplasm. Although the overall shape of NPCs is known, the details of this macromolecular complex have been obscure. Now, Lin
et al.
have reconstituted the pore components, determined the interactions between them, and fitted them into a tomographic reconstruction. Kosinski
et al.
have provided an architectural map of the inner ring of the pore.
Science
, this issue pp.
10.1126/science.aaf1015
and
363
Funder
Gordon and Betty Moore Foundation
Beckman Institute
Sanofi-Aventis Bioengineering Research Program
U.S. Department of Energy
National Institutes of Health (NIH)
National Cancer Institute
National Institute of General Medical Sciences
Deutsche Forschungsgemeinschaft
Boehringer Ingelheim Fonds
China Scholarship Council
Caltech
V Foundation
Edward Mallinckrodt Jr. Foundation
Sidney Kimmel Foundation
Camille-Dreyfus Teacher Scholar Award
NIH
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
222 articles.
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