Requirement for IL-13 Independently of IL-4 in Experimental Asthma-Reference-Cited by-同舟云学术

Requirement for IL-13 Independently of IL-4 in Experimental Asthma

Published:1998-12-18 Issue:5397 Volume:282 Page:2261-2263
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Grünig Gabriele¹,Warnock Martha¹,Wakil Adil E.¹,Venkayya Rajeev¹,Brombacher Frank¹,Rennick Donna M.¹,Sheppard Dean¹,Mohrs Markus¹,Donaldson Debra D.¹,Locksley Richard M.¹,Corry David B.¹

Affiliation:

1. G. Grünig, R. Venkayya, D. Sheppard, D. B. Corry, Departments of Medicine and the Lung Biology Center at the San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA. M. Warnock, Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA. A. E. Wakil, Department of Transplantation, California Pacific Medical Center, San Francisco, CA 94115, USA. F. Brombacher, Department of Immunology at the Groote Schuur Hospital,...

Abstract

The pathogenesis of asthma reflects, in part, the activity of T cell cytokines. Murine models support participation of interleukin-4 (IL-4) and the IL-4 receptor in asthma. Selective neutralization of IL-13, a cytokine related to IL-4 that also binds to the α chain of the IL-4 receptor, ameliorated the asthma phenotype, including airway hyperresponsiveness, eosinophil recruitment, and mucus overproduction. Administration of either IL-13 or IL-4 conferred an asthma-like phenotype to nonimmunized T cell–deficient mice by an IL-4 receptor α chain–dependent pathway. This pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL-4 receptor.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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