Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics-Reference-Cited by-同舟云学术

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

Published:2000-09 Issue:5484 Volume:289 Page:1567-1569
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Melov Simon¹,Ravenscroft Joanne²,Malik Sarwatt²,Gill Matt S.²,Walker David W.²,Clayton Peter E.²,Wallace Douglas C.³,Malfroy Bernard⁴,Doctrow Susan R.⁴,Lithgow Gordon J.²

Affiliation:

1. Buck Institute for Age Research, Novato, CA 94949, USA.

2. The School of Biological Sciences and the Academic Unit of Child Health, The University of Manchester, Manchester, M13 9PT, UK.

3. Center for Molecular Medicine, Emory University, Atlanta, GA 30322, USA.

4. Eukarion, Bedford, MA 01730, USA.

Abstract

We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean life-span by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their life-span (a 67 percent increase). It appears that oxidative stress is a major determinant of life-span and that it can be counteracted by pharmacological intervention.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference24 articles.

1. K. B. Beckman and B. N. Ames in Oxidative Stress and the Molecular Biology of Antioxidant Defences J. G. Scandalios Ed. (Cold Spring Harbor Laboratory Press Cold Spring Harbor NY 1997) chap. 8 pp. 201–246.

2. Beal M. F., Ann. Neurol. 38, 357 (1995).

3. Aging and resistance to oxidative damage in Caenorhabditis elegans.

4. Oxidative stress and ageing in Caenorhabditis elegans

5. Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogaster

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