Coagulation Factor X Activates Innate Immunity to Human Species C Adenovirus-Reference-Cited by-同舟云学术

Coagulation Factor X Activates Innate Immunity to Human Species C Adenovirus

Published:2012-11-09 Issue:6108 Volume:338 Page:795-798
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Doronin Konstantin¹,Flatt Justin W.²,Di Paolo Nelson C.¹,Khare Reeti¹,Kalyuzhniy Oleksandr³,Acchione Mauro⁴,Sumida John P.⁴,Ohto Umeharu⁵⁶,Shimizu Toshiyuki⁵⁶,Akashi-Takamura Sachiko⁷,Miyake Kensuke⁷⁸,MacDonald James W.⁹,Bammler Theo K.⁹,Beyer Richard P.⁹,Farin Frederico M.⁹,Stewart Phoebe L.²,Shayakhmetov Dmitry M.¹

Affiliation:

1. Department of Medicine, University of Washington, Seattle, WA 98195, USA.

2. Department of Pharmacology and Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, Cleveland, OH 44106, USA.

3. Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.

4. Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.

5. Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

6. RIKEN SPring-8 Center, Kouto 1-1-1, Sayo, Hyogo 679-5148, Japan.

7. Division of Innate Immunity, Department of Microbiology and Immunology, University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo 108-8639, Japan.

8. Laboratory of Innate Immunity, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo 108-8639, Japan.

9. Functional Genomics and Proteomics Core Facility, Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA.

Abstract

Wound Healing and Immunity Although wound healing and infection are often overlapping processes, whether the wound healing response modulates the immune response is not well understood. Doronin et al. (p. 795 , published online 27 September; see the Perspective by Herzog and Ostrov ) now show that coagulation factor X, an important component of the blood clotting cascade, helps to trigger antiviral immunity in response to adenovirus infection in mice. Factor X binds to human type C adenovirus with very high affinity. Structural analysis identified the critical binding residues between factor X and adenovirus, which, when mutated, inhibited binding. Despite being able to infect splenic macrophages in mice, transcriptional profiling of spleens from mice infected with a mutant adenovirus unable to bind to factor X revealed impaired activation of signaling cascades associated with innate immunity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference29 articles.

1. Innate Immune Recognition

2. The Danger Model: A Renewed Sense of Self

3. Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus

4. Angiotensin-converting enzyme 2 protects from severe acute lung failure

5. The Immunobiology of SARS

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