Molecular Basis for High Virulence of Hong Kong H5N1 Influenza A Viruses-Reference-Cited by-同舟云学术

Molecular Basis for High Virulence of Hong Kong H5N1 Influenza A Viruses

Published:2001-09-07 Issue:5536 Volume:293 Page:1840-1842
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Hatta Masato¹,Gao Peng¹,Halfmann Peter¹,Kawaoka Yoshihiro¹²

Affiliation:

1. Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin–Madison, 2015 Linden Drive, Madison, WI 53706, USA.

2. Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

Abstract

In 1997, an H5N1 influenza A virus was transmitted from birds to humans in Hong Kong, killing 6 of the 18 people infected. When mice were infected with the human isolates, two virulence groups became apparent. Using reverse genetics, we showed that a mutation at position 627 in the PB2 protein influenced the outcome of infection in mice. Moreover, high cleavability of the hemagglutinin glycoprotein was an essential requirement for lethal infection.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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5. Biological Heterogeneity, Including Systemic Replication in Mice, of H5N1 Influenza A Virus Isolates from Humans in Hong Kong

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