Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques-Reference-Cited by-同舟云学术

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

Published:2017-10-06 Issue:6359 Volume:358 Page:85-90
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Xu Ling¹,Pegu Amarendra²^ORCID,Rao Ercole¹^ORCID,Doria-Rose Nicole²^ORCID,Beninga Jochen¹^ORCID,McKee Krisha²,Lord Dana M.¹^ORCID,Wei Ronnie R.¹,Deng Gejing¹,Louder Mark²^ORCID,Schmidt Stephen D.²^ORCID,Mankoff Zachary²,Wu Lan¹,Asokan Mangaiarkarasi²,Beil Christian¹^ORCID,Lange Christian¹^ORCID,Leuschner Wulf Dirk¹^ORCID,Kruip Jochen¹^ORCID,Sendak Rebecca¹^ORCID,Do Kwon Young²^ORCID,Zhou Tongqing²^ORCID,Chen Xuejun²^ORCID,Bailer Robert T.²,Wang Keyun²,Choe Misook²^ORCID,Tartaglia Lawrence J.³⁴^ORCID,Barouch Dan H.³⁴^ORCID,O’Dell Sijy²,Todd John-Paul²,Burton Dennis R.⁴⁵^ORCID,Roederer Mario²^ORCID,Connors Mark⁶^ORCID,Koup Richard A.²,Kwong Peter D.²^ORCID,Yang Zhi-yong¹,Mascola John R.²^ORCID,Nabel Gary J.¹^ORCID

Affiliation:

1. Sanofi, 640 Memorial Drive, Cambridge, MA 02139, USA.

2. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.

3. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

4. Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.

5. Department of Immunology and Microbiology, International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.

6. National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.

Abstract

A triple threat for HIV The HIV virus continually evolves tricks to evade elimination by the host. Prevention and a cure will likely rely on broadly neutralizing antibodies that can recognize and conquer multiple viral strains or subtypes. Xu et al. engineered a single antibody molecule to recognize three highly conserved proteins needed for HIV infection (see the Perspective by Cohen and Corey). This “trispecific” antibody uses two sites (V1V2 and MPER) to bind HIV-infected cells, while the third site (CD4bs) recruits killer T lymphocytes that can eliminate the virus. When tested against >200 different HIV strains, trispecific antibodies were highly potent and broadly neutralized ∼99% of HIV viruses. This approach could potentially simplify HIV treatment regimens and improve therapy response. Science , this issue p. 85 ; see also p. 46

Funder

Intramural Research Program of the Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH

Sanofi R&D

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference48 articles.

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