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Complex Riboswitches

Published:2008-03-28 Issue:5871 Volume:319 Page:1795-1797
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Breaker Ronald R.¹

Affiliation:

1. Department of Molecular, Cellular and Developmental Biology, Department of Molecular Biophysics and Biochemistry, and Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA.

Abstract

Using simple biochemical tricks, metabolite-binding riboswitches take on gene control functions that have long been thought to be the work of protein factors. Although modern riboswitches might be the last holdouts of primitive genetic elements, some are capable of sensory and regulatory feats that are competitive with their protein counterparts.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference32 articles.

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4. R. R. Breaker, in The RNA World, R. F. Gesteland, T. R. Cech, J. F. Atkins, Eds. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, ed. 3, 2006), pp. 89–107.

5. Nucleic Acid Selection and the Challenge of Combinatorial Chemistry

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