Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia

Author:

Das Suman K.1,Eder Sandra2,Schauer Silvia1,Diwoky Clemens3,Temmel Hannes1,Guertl Barbara1,Gorkiewicz Gregor1,Tamilarasan Kuppusamy P.1,Kumari Pooja14,Trauner Michael4,Zimmermann Robert2,Vesely Paul1,Haemmerle Guenter2,Zechner Rudolf2,Hoefler Gerald1

Affiliation:

1. Institute of Pathology, Medical University of Graz, 8036 Graz, Austria.

2. Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria.

3. Institute of Medical Engineering, Graz University of Technology, 8010 Graz, Austria.

4. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria.

Abstract

Ablation of a gene controlling fat breakdown can protect mice from cancer-associated uncontrolled loss of fat and muscle. 10.1126/science.1198973

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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