NMR Detection of Structures in the HIV-1 5′-Leader RNA That Regulate Genome Packaging

Author:

Lu Kun1,Heng Xiao1,Garyu Lianko1,Monti Sarah1,Garcia Eric L.2,Kharytonchyk Siarhei2,Dorjsuren Bilguujin1,Kulandaivel Gowry1,Jones Simonne1,Hiremath Atheeth1,Divakaruni Sai Sachin1,LaCotti Courtney1,Barton Shawn1,Tummillo Daniel1,Hosic Azra1,Edme Kedy1,Albrecht Sara1,Telesnitsky Alice2,Summers Michael F.1

Affiliation:

1. Howard Hughes Medical Institute (HHMI) and Department of Chemistry and Biochemistry, University of Maryland Baltimore County (UMBC), 1000 Hilltop Circle, Baltimore, MD 21250, USA.

2. Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109–0620, USA.

Abstract

An RNA structural switch regulates whether the HIV genome is translated or dimerized and packaged.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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