The Inhibitory Circuit Architecture of the Lateral Hypothalamus Orchestrates Feeding-Reference-Cited by-同舟云学术

The Inhibitory Circuit Architecture of the Lateral Hypothalamus Orchestrates Feeding

Published:2013-09-27 Issue:6153 Volume:341 Page:1517-1521
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Jennings Joshua H.¹²,Rizzi Giorgio¹³,Stamatakis Alice M.¹²,Ung Randall L.¹,Stuber Garret D.¹²⁴⁵⁶

Affiliation:

1. Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

2. Neurobiology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

3. Master program Neuroscience and Cognition, Brain Center Rudolf Magnus, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht 3584 CX, Netherlands.

4. Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

5. Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

6. Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Abstract

The Overeating Connection Obesity has become a major global health problem. Working in mice, Jennings et al. (p. 1517 ) identified an important brain circuit within the lateral hypothalamus that modulates food intake. The findings reveal the neuronal connections that drive the consumption of highly palatable food even when energy needs are satisfied. Inhibition of this circuit suppressed feeding.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference27 articles.

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4. Lateral hypothalamic injections of glutamate, kainic acid,d,l-α-amino-3-hydroxy-5-methyl-isoxazole propionic acid or N-methyl-d-aspartic acid rapidly elicit intense transient eating in rats

5. GABAA receptors in the lateral hypothalamus as mediators of satiety and body weight regulation

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