Aggregation platelets function in persons with vibration disease

Abstract

The article considers the changes in the rheological properties of blood and the aggregation function of platelets in interns exposed to local vibration and combined effects of local and general vibration. In recent years, the medical and social significance of vibration disease (VD) as a disease is associated with the loss of working capacity and the young age of people who have lost their professional ability to work. In confirmation of this, we can observe a high incidence of VD among workers of aircraft factories, in the mining industry, among operators of heavy vehicles and construction equipment. The study aims to consider the aggregation activity of platelets in persons with vibration disease during exposure to local vibration and combined exposure to local and general vibration, to draw attention to the need to study the aggregation function of platelets in persons with occupational diseases. Group one consisted of 47 patients with vibration disease from exposure to local vibration, group two included 52 patients with vibration disease from combined exposure to local and general vibration. In these groups, the researchers observed the induced platelet aggregation activity on an optical aggregometer using an adenosine diphosphate (ADP) inductor at concentrations of 5.0, 2.5, 0.1 μM/L. The authors have carried out statistical processing of the results. We have taken the differences as statistically significant at p≤0.05. Persons with vibration disease had reduced indicators of platelet aggregation activity in comparison with reference values, the number of platelets and thrombocrit in the blood within normal limits. At the same time, the correlation analysis showed the presence of positive correlations between the aggregatogram indicators under the action of an inductor of high (5.0 mmol/L) and low concentrations (2.5 mmol/L), 0.1 mmol/L). Evaluation of platelet aggregation activity in individuals with vibration disease with exposure to local vibration and with combined exposure to local and general vibration established low response rates in response to the introduction of an inducer (lower than reference), in more than 50% of cases, indicating "depletion of platelets". The study of the induced platelet activity did not reveal the peculiarities of its manifestation both in persons exposed to local vibration and in workers exposed to the combined effects of local and general vibration. Limitations. Limitations of the study may be differences in the methodology and reference intervals of the study of aggregation activity in different laboratories and a small sample of patients included in this study. Ethics. All patients had previously signed an informational consent to participate in the study. The research plan, the content of the informed consent to participate in the research, as well as the materials of the article were approved by the local Ethics committee of the East Siberian Institute of Medical and Environmental Research.