Inflammatory Responses with Left Ventricular Compromise after Induction of Myocardial Infarcts in Sheep (Ovis aries)

Author:

Gordon Hylton P1,Katz Michael G2,Fazal Shahood2,Gillespie Virginia L3,Fargnoli Anthony S2,Gubara Sarah M2,Madjarova Sophia J4,Cohen Jonathan A3

Affiliation:

1. Center for Comparative Medicine and Surgery, Icahn School of Medicine at Mt. Sinai, New York, New York;, Email: hylton.gordon@mssm.edu

2. Department of Cardiology, Icahn School of Medicine at Mt. Sinai, New York, New York

3. Center for Comparative Medicine and Surgery, Icahn School of Medicine at Mt. Sinai, New York, New York

4. Department of Biology, Columbia University School of Medicine, New York, New York

Abstract

Ischemic myocardial disease is a major cause of death among humans worldwide; it results in scarring and pallor of the myocardium and triggers an inflammatory response that contributes to impaired left ventricular function. This response includes and is evidenced by the production of several inflammatory cytokines including TNFα, IL1β, IL4, IFNγ, IL10 and IL6. In the current study, myocardial infarcts were induced in 6 mo old male castrated sheep by ligation of the left circumflex obtuse marginal arteries (OM 1 and 2). MRI was used to measure parameters of left ventricular function that include EDV, ESV, EF, SVI, dp/dt max and dp/dt min at baseline and at 4 wk and 3 mo after infarct induction. We also measured serum concentrations of an array of cytokines. Postmortem histologic findings corroborate the existence of left ventricular myocardial injury and deterioration. Our data show a correlation between serum cytokine concentrations and the development of myocardial damage and left ventricular functional compromise.

Publisher

American Association for Laboratory Animal Science

Subject

General Veterinary,General Biochemistry, Genetics and Molecular Biology

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