Association between nitric oxide and cancer and stroke risk: A meta-analysis

Abstract

Background: Numerous case-control studies have been carried out to test the mechanism by which nitric oxide, specifically the polymorphism 894G>T in the eNOS gene, or endothelial nitric oxide synthase, raises the possibility of stroke and cancer. Methods: The aim of this meta-analysis was to describe the correlation between cancer and stroke risk with nitric oxide, by implementing a comprehensive search in various digital databases, including Science Direct, PubMed, and Google Scholar, in the period 2012-2023 to observe the published results of all related studies. Results: The meta-analysis included a total of fifteen case-control studies. These studies involved 3,019 cases and 3,333 controls in total. This study found that the GGversusGT+TT genotype of eNOS 894G>T polymorphism was significantly positively correlated with cancer risk. Additionally, the significance of this association was further attributed to the specific type of polymorphism involved, as well as the risk of stroke in the TversusG model, followed by TTversusGG+GT.Conclusions: The results of the eNOS 894G>T polymorphisms have been correlated with cancer, and in particular, the GT+TT versusGG model yielded an odds ratio (OR of 1.96, a 95% CI of 1.22 to 3.15, and ap-value of 0.0005. Moreover, the mentioned polymorphisms were found to be associated with stroke risk in the TversusG model, which had an OR of 1.20; 95% CI of 1.01 to 1.43 with ap-value of 0.04; and TTversusGG+GT with an OR of 0.09; 95% CI of 0.03 to 0.30 with ap-value of0.0001.