Abstract
Flavohaemoglobins were first described in yeast as early as the 1970s but their functions were unclear. The surge in interest in nitric oxide biology and both serendipitous and hypothesis-driven discoveries in bacterial systems have transformed our understanding of this unusual two-domain globin into a comprehensive, yet undoubtedly incomplete, appreciation of its pre-eminent role in nitric oxide detoxification. Here, I focus on research on the flavohaemoglobins of microorganisms, especially of bacteria, and update several earlier and more comprehensive reviews, emphasising advances over the past 5 to 10 years and some controversies that have arisen. Inevitably, in light of space restrictions, details of nitric oxide metabolism and globins in higher organisms are brief.
Funder
Biotechnology and Biological Sciences Research Council
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference128 articles.
1. NO More Heart Disease;L Ignarro,2005
2. Life, Death and Nitric Oxide;A Butler,2003
3. Diffusivity and solubility of nitric oxide in water and saline.;I Zacharia;Ann Biomed Eng.,2005
4. New functions for the ancient globin family: bacterial responses to nitric oxide and nitrosative stress.;R Poole;Mol Microbiol.,2000
5. Small molecule signaling agents: the integrated chemistry and biochemistry of nitrogen oxides, oxides of carbon, dioxygen, hydrogen sulfide, and their derived species.;J Fukuto;Chem Res Toxicol.,2012
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