Outbreaks of COVID-19 in a tuberculosis treatment sanatorium on the Thailand-Myanmar border: a retrospective cohort analysis

Author:

Aung Htet Ko KoORCID,Swe Lei Lei,Saito Makoto,Lesseps Sophie,Janurian Naw,Tun Win Pa Pa,Maung Maung Banyar,Than Aung,Watthanaworawit Wanitda,Kaewphanderm Napaporn,Gornsawun Gornpan,Pyae Phyo AungORCID,Nosten FrançoisORCID

Abstract

Background: Tuberculosis (TB) is a chronic condition, with overlapping symptoms to those of coronavirus disease 2019 (COVID-19). There has been inconsistent evidence on whether TB is a predisposing factor for developing severe COVID-19. The aim of this report is to explore whether TB influences the severity of COVID-19. Methods: COVID-19 cases at two TB sanatoria on the Thailand-Myanmar border were reviewed. Demographic, clinical and laboratory data including TB treatment and co-morbidities, were analyzed. Characteristics and COVID-19 clinical outcomes were compared between two groups of patients: TB and those without TB (the caretakers and the medical personnel). Multivariable ordered logistic regression was conducted to compare the risk of severe COVID-19 between the two groups. Results: Between September 2021 and March 2022, 161 COVID-19 cases were diagnosed. Over half of the COVID-19 patients were infected with TB (n= 104, 64.6%), and the rest were not (n=57, 35.4%). The median (interquartile range) age was 48 (33.5-57.0) and 27 (23-33) years in the TB and in the non-TB COVID-19 patients, respectively. Before COVID-19 infection, 78.7% (122/155) of patients had received at least one dose of COVID-19 vaccine. The median cycle threshold value at diagnosis was not different between TB (18.5, IQR 16.1-32.3) and non-TB patients (18.8, 15.1-30.0). Fever, gastrointestinal symptoms and ageusia were more common in non-TB patients. Six patients (3.8%, 6/156) all from the TB group became severe of which five (3.2%, 5/156) required oxygen therapy. One TB patient died (1/104, 0.96%) of lung cancer. After adjustment for potential confounders, the final clinical severity was not different between the two groups (adjusted odds ratio 1.21, 95% confidence interval 0.45–3.28). Conclusions: TB was not associated with severe outcomes in the two TB sanatoria. The high uptake of COVID-19 vaccination and active screening could have impacted on disease progression and prevented unfavorable outcomes.

Funder

Wellcome

Publisher

F1000 Research Ltd

Subject

General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)

Reference25 articles.

1. Global Tuberculosis Report 2021.,2021

2. The Myanmar-Thailand Development Cooperation Programme on Health (2020-2022)_Draft.,2020

3. An Evaluation of Awareness and Preparedness on Infectious and Emerging Diseases at the Cross Border Areas; Thailand - Myanmar - Cambodia – Lao PDR Project in the Fiscal year 2015-2017 (การประเมินผลโครงการสร้างความตระหนักและเตรียมความพร้อมสำหรับโรคติดต่อและโรคอุบัติใหม่ตามแนวพรมแดนไทย–ราชอาณาจักรกัมพูชา–สาธารณรัฐประชาธิปไตย ประชาชนลาว – สาธารณรัฐแห่งสหภาพเมียนมา ปีงบประมาณ 2558-2560).;P Kanthawee,2020

4. Clinical Characteristics, Diagnosis, Treatment, and Mortality Rate of TB/COVID-19 Coinfectetd Patients: A Systematic Review.;M Koupaei;Front Med (Lausanne).,2021

5. Effects of tuberculosis and/or HIV-1 infection on COVID-19 presentation and immune response in Africa.;E du Bruyn;Nat Commun.,2023

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3