Neuromuscular assessment of force development, postural, and gait performance under cognitive-motor dual-tasking in healthy older adults and early Parkinson's disease patients: Study protocol for a cross-sectional Mobile Brain/Body Imaging (MoBI) study

Author:

Marusic UrosORCID,Peskar MancaORCID,Šömen Maja Maša,Kalc Miloš,Holobar Ales,Gramann Klaus,Wollesen Bettina,Wunderlich AnnaORCID,Michel Christoph,Miladinović Aleksandar,Catalan Mauro,Buoite Stella Alex,Ajcevic Milos,Manganotti Paolo

Abstract

Background: Neuromuscular dysfunction is common in older adults and more pronounced in neurodegenerative diseases. In Parkinson's disease (PD), a complex set of factors often prevents the effective performance of activities of daily living that require intact and simultaneous performance of the motor and cognitive tasks. Methods: The cross-sectional study includes a multifactorial mixed-measure design. Between-subject factor grouping the sample will be Parkinson’s Disease (early PD vs. healthy). The within-subject factors will be the task complexity (single- vs. dual-task) in each motor activity, i.e., overground walking, semi-tandem stance, and isometric knee extension, and a walking condition (wide vs. narrow lane) will be implemented for the overground walking activity only. To study dual-task (DT) effects, in each motor activity participants will be given a secondary cognitive task, i.e., a visual discrimination task for the overground walking, an attention task for the semi-tandem, and mental arithmetic for the isometric extension. Analyses of DT effects and underlying neuronal correlates will focus on both gait and cognitive performance where applicable. Based on an a priori sample size calculation, a total N = 42 older adults (55-75 years) will be recruited. Disease-specific changes such as laterality in motor unit behavior and cortical control of movement will be studied with high-density surface electromyography and electroencephalography during static and dynamic motor activities, together with whole-body kinematics. Discussion: This study will be one of the first to holistically address early PD neurophysiological and neuromuscular patterns in an ecologically valid environment under cognitive-motor DT conditions of different complexities. The outcomes of the study aim to identify the biomarker for early PD either at the electrophysiological, muscular or kinematic level or in the communication between these systems.  Clinical Trial Registration: ClinicalTrials.Gov, NCT05477654. This study was approved by the Medical Ethical Committee (106/2021).

Funder

Horizon 2020 Framework Programme

Javna Agencija za Raziskovalno Dejavnost RS

Publisher

F1000 Research Ltd

Subject

Multidisciplinary

Reference80 articles.

1. Parkinson disease.;W Poewe;Nat Rev Dis Primers.,2017

2. Epidemiology of Parkinson’s disease.;O Tysnes;J Neural Transm (Vienna).,2017

3. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson’s disease.;W Gibb;J Neurol Neurosurg Psychiatry.,1988

4. Parkinson’s disease: clinical features and diagnosis.;J Jankovic;J Neurol Neurosurg Psychiatry.,2008

5. Falls and freezing of gait in Parkinson’s disease: a review of two interconnected, episodic phenomena.;B Bloem;Mov Disord.,2004

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3