Risk Factors for Postoperative Disseminated Intravascular Coagulation in Surgical Patients with Non-occlusive Mesenteric Ischemia

Abstract

Abstract Purpose The prognostic impact of disseminated intravascular coagulation (DIC) in surgical patients with non-occlusive mesenteric ischemia (NOMI) is unclear. This study aimed to confirm the association between postoperative DIC and prognosis and to identify preoperative risk factors associated with postoperative DIC.Methods This retrospective study included 52 patients who underwent emergency surgery for NOMI between January 2012 and March 2022. Kaplan–Meier curve analysis with the log-rank test was used to compare 30-day survival and hospital survival between patients with and without postoperative DIC. In addition, univariate and multivariate logistic regression analyses were performed to identify the preoperative risk factors for postoperative DIC.Results The 30-day and hospital mortality rates were 30.8% and 36.5%, respectively, and the incidence rate of DIC was 51.9%. Compared to patients without DIC, patients with DIC showed significantly lower rates of 30-day survival (41.5% vs 96%, log-rank P < 0.001) and hospital survival (30.2% vs 86.4%, log-rank, P < 0.001). Logistic regression analyses showed that the Japanese Association for Acute Medicine (JAAM) DIC score (OR = 2.697; 95% CI, 1.408–5.169; P = 0.003) and Sequential Organ Failure Assessment (SOFA) score (OR = 1.511; 95% CI, 1.111–2.055; P = 0.009) were independent risk factors for postoperative DIC in surgical patients with NOMI.Conclusion The development of postoperative DIC is a significant prognostic factor for 30-day and hospital mortality in surgical patients with NOMI. In addition, the JAAM DIC score and SOFA score have a high discriminative ability for predicting the development of postoperative DIC.