Insulin Resistance in Multiple Organs and Systems

Abstract

AbstractInsulin resistance (IR) is a biological response to insulin stimulation in target tissues. IR alters glucose metabolism, resulting in increased insulin production by beta-cells. The primary condition associated with IR is obesity, which is often caused by environmental factors, particularly diet.Objective: To describe IR in various organs and present a signaling pathway project.Methods: The PubMed database was used to search for IR review publications. The referenced data for the signaling pathway were selected by aggregating references from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. A signaling pathway was designed based on IR research manuscripts, which show various mechanisms involved. The KEGG server was used to explore protein-protein interactions and create a signaling pathway diagram. The signaling path was mapped using PathVisio software, adapted to the model of the KEGG PATHWAY Database: https://www.genome.jp/pathway/map04930.Results: Articles featuring the terms “insulin resistance” and “signaling pathway” were selected from the PubMed database. Based on validated research articles, well-founded pathways were chosen and a representative description of these pathways was achieved. Reproduction contigs from the KEGG database projected the signaling pathway of biomolecules leading to IR. Thus, the interaction between multiple mechanisms releases factors that contribute to the development of IR.Conclusion: The interaction between multiple mechanisms and molecular interactions are important factors in the development of IR in various organs and systems.