Survival and predictors of mortality in patients with heart failure in the cardiology department of the Center Hospitalier Basse Terre in Guadeloupe: Historical cohort study

Abstract

Abstract Background : Despite the progress made in recent years in the treatment of Heart Failure (HF), its prognosis remains poor in the developing country. The objective of this study is to analyze the survival and predictors of mortality of patients with heart failure in the cardiology department of the Basse Terre Hospital Center in Guadeloupe. Methods: this was a historical cohort study carried out over a period from June 2021 to June 2022, targeting all heart failure patients undergoing cardiac monitoring in the cardiology department of the Basse Terre Hospital Center in Guadeloupe. Sociodemographic, clinical, biological characteristics and outcome (recovery or death) were studied. Survival was described using the Kaplan Meier method α=5%. Results: this study involved 242 heart failure patients whose median age was 75 years and the majority were male (sex ratio 2M/1F). Among these patients, 14.9% died, the most common cause of death was cardiogenic shock (52.8%). After adjustment, tobacco consumption (aHR: 2.90; 95% CI: 1.36-8.09), CKD (aHR: 2.52; 95% CI: 1.22-5.20), infection (aHR: 2.14; 95CI %: 1.99-4.58), hyponatremia (aHR: 1.90; 95% CI: 1.10-2.86), mitral regurgitation (aHR: 3.04; 95% CI: 1.98-9.47) and NTproBNP >10000ng/ml (aHR: 2.57; 95% CI: 1.21-5.49) were independently associated with the risk of death in heart failure patients. Conclusion: HF causes high mortality due mainly to cardiogenic shock and factors of multi-organ failure.