Low mean hemoglobin is associated with postoperative cerebral ischemia complications of moyamoya disease

Abstract

Hemoglobin(HB)has been shown to be associated with poor prognosis in several cardiovascular diseases. There are limited studies on HB and postoperative cerebral ischemia complications of moyamoya disease (MMD). The objective of this study is to examine the relationship between postoperative cerebral ischemic complications of MMD and HB, with the aim of developing a predictive model. We collected demographic information as well as multiple hemoglobin values (minimum HB, maximum HB, mean HB, preoperative HB,postoperative HB from 115 patients with MMD, 37 of whom developed symptoms of cerebral ischemia after revascularization.Multivariate logistic regression methods showed that mean HB was an independent risk factor for cerebral ischemic complications in MMD(p = 0.015). The restricted cubic spline to further explored and visualize the association between them.The Analysis of the area under the receiver operating characteristic curve (AUC) value was 0.850. The Decision curve analysis (DCA) curve showed that the individual threshold probability ranged from 7–95%. In our study, low mean HB was significantly associated with cerebral ischemic complications of MMD after revascularization, but not with patient mortality. We also created a column-line diagram about them. It suggested that low mean HB is an independent risk factor for cerebral ischemic complications of MMD revascularization.