Epidemiology of hand, foot, and mouth disease and genetic characteristics of Coxsackievirus A10 in Taiyuan City, Shanxi Province from 2016

Epidemiology of hand, foot, and mouth disease and genetic characteristics of Coxsackievirus A10 in Taiyuan City, Shanxi Province from 2016–2020

Published:2023-02-17 Issue: Volume: Page:
ISSN:
Container-title:
language:
Short-container-title:

Author:

Wang Jitao¹,Liu Hongyan¹,Cao Zijun¹,Xu Jihong²,Guo Jiane²,Zhao Lifeng²,Wang Rui²,Xu Yang²,Gao Ruihong²,Gao Li²,Zuo Zhihong²,Xiao Jinbo³,Lu Huanhuan³,Zhang Yong³

Affiliation:

1. Health，Shanxi Medical University

2. Taiyuan Center for Disease Control and Prevention

3. National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention

Abstract

Abstract In recent years, the prevalence of hand, foot, and mouth disease (HFMD)caused by enteroviruses other than enterovirus A71 (EV-A71) and coxsackievirus A16 (CVA16) has gradually increased. The throat swab specimens of 2701 HFMD cases were tested, the VP1 regions of CVA10 RNA were amplified using RT-PCR, and phylogenetic analysis of CVA10 was performed. Children aged 1–5 years accounted for the majority (81.65%) and boys was more than girls. The positivity rates of EV-A71, CVA16, and other EVs were 15.22% (219/1439), 28.77% (414/1439), and 56.01% (806/1439), respectively. CVA10 is one of the important viruses of other EVs. A total of 52 CVA10 strains were used for phylogenetic analysis based on the VP1 region, 31 were from this study, and 21 were downloaded from GenBank. All CVA10 sequences could be assigned to seven genotypes (A, B, C, D, E, F, and G), and genotype C was further divided into C1 and C2 subtypes, only one belonged to subtype C1 and the remaining 30 belonged toC2 in this study. This study emphasized the importance of strengthening the surveillance of the HFMD in order to understand the mechanisms of pathogen variation and evolution, so as to provide a scientific basis for HFMD prevention, control, and vaccine development.

Publisher

Research Square Platform LLC

Reference30 articles.

1. 1. Shah VA, Chong CY, Chan KP, Ng W, Ling AE: Clinical characteristics of an outbreak of hand, foot and mouth disease in Singapore. Ann Acad Med Singap 2003, 32(3):381–387.

2. 2. Xing W, Liao Q, Viboud C, Zhang J, Sun J, Wu JT, Chang Z, Liu F, Fang VJ, Zheng Y et al: Hand, foot, and mouth disease in China, 2008-12: an epidemiological study. Lancet Infect Dis 2014, 14(4):308–318.

3. 3. Zhang Y, Xu WB: Molecular epidemiology of enteroviruses associated with hand, foot, and mouth disease in the mainland of China. Biomedical and environmental sciences : BES 2013, 26(11):875–876.

4. 4. Knowles NJ, Hovi T, Hyypiä, T., King AMQ, Lindberg AM, Pallansch MA, Palmenberg AC, Simmonds P, Skern T, Stanway G, Yamashita T et al: Picornaviridae. In: Virus taxonomy: classification and nomenclature of viruses: Ninth Report of the International Committee on Taxonomy of Viruses. Ed: King, A.M.Q., Adams, M.J., Carstens, E.B. and Lefkowitz, E.J. San Diego: Elsevier 2012:855–880.

5. 5. Chang LY, Lin TY, Hsu KH, Huang YC, Lin KL, Hsueh C, Shih SR, Ning HC, Hwang MS, Wang HS et al: Clinical features and risk factors of pulmonary oedema after enterovirus-71-related hand, foot, and mouth disease. Lancet 1999, 354(9191):1682–1686.

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Effectiveness of EV-A71 Vaccine and Its Impact on the Incidence of Hand, Foot and Mouth Disease: A Systematic Review;Vaccines;2024-09-08