The correlation of bioactive components between human female adult peripheral and umbilical cord blood platelet-rich plasma

Abstract

Abstract Background: Few studies have reported the components, especially anti-aging related substances of umbilical cord blood-derived platelet-rich plasma( PRP). Objective: The aim of this study was to compare the concentrations of bioactive components in PRP from healthy female adults and umbilical cord blood-derived PRP. Methods: Prepare PRP with blood samples from 4 different female age groups (12 in each group): Group A, umbilical cord blood (UCB) of female neonates; Group B: aged 18-25years; Group C: aged 26-45 years; Group D: aged 46-65 years. The concentrations of epidermal growth factor (EGF), basic fibroblast growth factor-2 (FGF-2), insulin-like growth factor-1 (IGF-1), PLT-derived growth factor-AA (PDGF-AA), PLT-derived growth factor-AB/BB (PDGF-AB/BB), vascular endothelial growth factor A (VEGF-A), RANTES, TIMP1, TIMP2, GDF11, Clusterin and activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) in the PRP samples were determined and compared. Results: There are statistically significant differences in the concentration of anti-aging related bioactive components, FGF-2, PDGF-AB/BB, Clusterin and GPx activity in PRP between different groups. Conclusion: PRP prepared by UCB contains a variety of active ingredients including anti-aging proteins. Due to its rich source and low immunogenicity, the use of UCB to prepare PRP is an important research direction in the future.