Urgent incontinence increases the risk of all-cause and cardiovascular mortality in people with diabetes

Abstract

Abstract Background Studies on the association between urinary incontinence and all-cause and cardiovascular mortality in diabetic populations are limited, and further studies are needed to investigate this association. Methods Data were collected from the National Health and Nutrition Survey database (2001–2018). Inclusion and exclusion criteria were established. A cohort of 4819 individuals was included. Multivariate weighted Cox regression analysis was performed to comprehensively explore the relationship between urinary incontinence and all-cause and cardiovascular disease mortality in the diabetic population. Subgroup analysis was performed to explore heterogeneity. Results In the study on the effect of urge incontinence on all-cause mortality, after adjusting for all covariates, all-cause mortality occurred in diabetic subjects with urge incontinence compared with subjects without urge incontinence. OR = 1.33, 95% CI 1.15–1.54. Also in the study of urge incontinence versus cardiovascular death in diabetic patients, cardiovascular death occurred in diabetic patients with urge incontinence compared with subjects without urge incontinence. OR = 1.32, 95%CI 1.02–1.72. Subgroup analysis showed that there were two interacting covariates, and the relationship was still significant after removing variables. The results of multivariate Cox regression for all-cause death and cardiovascular disease death showed OR = 1.36, 95%CI 1.17–1.58; OR = 1.35, 95%CI 1.02–1.78. No significant association was found between stress incontinence and mixed incontinence. Conclusions Our results suggest a positive impact of urge incontinence on all-cause and cardiovascular mortality in diabetic patients. Further studies are needed to elucidate the causal relationship between urge incontinence and all-cause and cardiovascular mortality in diabetic patients.