Abstract
To compare the effect of different surgical methods on the prognosis of patients with colon cancer. 360 patients undergoing laparoscopic radical resection of rectal cancer werei ncluded. Patients' general information, hospital moriality and surgical complications were recorded. The immunological indexes and inflammatory factor levels of patients were dynamically recorded before surgery, and at the first, third and fifth days after surgery. Compared with groups A and C, the intraoperative dosage of propofol, remifentanil and cisatracurium in group B was lower (p < 0.05), the number of vasoactive drug users and the incidence of postoperative chills were lower (p< 0.05), the probability of vomiting was lower in group B and group C; The cell counts of CD3 + T, CD4 + T, CD4/CD8 and NK in group B were higher than those in group A and C on day 1 and day 3 after surgery (p < 0.05), the CD3 + T, CD4 + T and NK cell counts of group C were higher than those of group A on the first and third days after surgery, while the IL-6, CRP, WBC and IFN-a counts of group B and C were lower than those of group A. Groups B and C had lower postoperative pain scores, lower use of postoperative analgesics, and shorter hospital times. General anesthesia combined epidural block can reduce postoperative immunosuppression and inflammatory response in patients with rectal cancer, and reduce intraoperative anesthetic drug dosage and adverse anesthesia reactions.