Lung function impairment may increase secondary thrombocytopenia susceptibility: a Mendelian randomization

Abstract

Abstract Purpose This study explored the relationship between lung function and secondary thrombocytopenia by analyzing Mendelian randomization (MR). Methods As instrumental genetic variables, appropriate single nucleotide polymorphisms (SNPs) were extracted from genome-wide association study (GWAS) data on lung function. We choose secondary thrombocytopenia as the outcome. Inverse variance weighting, weighted median methods, and MR- Egger's method were used to explore the association between lung function and the risk of secondary thrombocytopenia. The analysis results were shown as odds ratio (OR) and 95% confidence interval to evaluate the causal association between lung function parameters and secondary thrombocytopenia. Results The inverse variance weighted (IVW) analysis showed that forced expiratory volume in the first second (FEV1) significantly led to the occurrence of secondary thrombocytopenia [OR: 0.2126; 95% confidence interval (CI): 0.0508–0.8886, P = 0.0339], reduced peak expiratory flow (PEF) increased the occurrence of secondary thrombocytopenia [OR: 0.1018; 95% CI: 0.0143–0.7234, P = 0.0224]. The decline of FEV1 and PEF contributed to the risk of secondary thrombocytopenia. Furthermore, FVC (Forced Vital Capacity), FEV1/FVC, and lung volume were not associated with secondary thrombocytopenia. Conclusion FEV1 and PEF could be important precipitating factors of secondary thrombocytopenia, which provided new ideas for treating and preventing secondary thrombocytopenia.