Lung Cancer Cell Detection by a MoS 2 Biosensing Chip

Abstract

Abstract In this study, a biosensor chip was fabricated using MoS2, which is used to detect and analyze the level of cancerization in lung cancer cells. Cancer is the leading cause of mortality worldwide, accounting for over 10 million deaths in 2022, or roughly one death in every six patients. Consequently, society places a high value on cancer prevention and treatment methods. Thus, developing the quickest method to detect cancer and provide correct analytical information for the clinic at an early stage of cancer is very important. It has constantly been the focus of reciprocal relationships and collaborative efforts between the academic and medical sectors. The MoS2 thin film was grown on the light-absorbing layer substrate of silicon-based solar elements through chemical vapor deposition and combined with a self-designed serrated interdigitated electrode (SIE) through the carrier transport mechanism of photogenerated charges. The three types of lung cancer cell clinical samples—CL1, NCI-H460, and NCI-H520 cell lines were subjected to photoelectric flow measurement. The experimental results showed that the R-Square of the linear fitting curve was approximately 98%. In addition, the device was enhanced by 38% when a double-layer MoS2 film was added. GSSGs reaction analysis can be further enhanced.