The Effects Of Injectable Platelet-Rich Fibrin Application On Wound Healing Following Gingivectomy and Gingivoplasty Operations: single-blind, randomized controlled, prospective clinical study

Abstract

Abstract Objectives The study aims to evaluate the effects of injectable platelet-rich fibrin (I-PRF) applications on early wound healing after gingivectomy and gingivoplasty surgery. Materials and Methods In this study, gingivectomy and gingivoplasty surgeries were performed on two groups. I-PRF (n = 23) was applied and compared with control group (n = 23). The surgical areas were stained with Mira-2 tone and evaluated in the ImageJ program. Wound healing was evaluated by using the Modified Manchester Scar (MMS) scale and Landry, Turnbull, and Howley (LTH) index. Vascular endothelial growth factor (VEGF) and fibroblast growth factor 10 (FGF-10) concentrations were assessed by enzyme-linked immunoabsorbent assay (ELISA). The seven-day Visual Analog Scale was used to assess pain level. Results The amount of staining with Mira-2 tone was found to be significantly higher in the control group than in the test group on days 3, 7, and 14. LTH index values ​​of the control group were significantly lower than the test group, and MMS scale values ​​were significantly higher than those of the test group. VEGF values of the control group at baseline, week 2, and week 3 were significantly higher than the test group. In weeks 2 and 3, FGF-10 values were found to be significantly higher in the control group than in the test group. Conclusions I-PRF applications revealed positive effects on epithelial wound healing after gingivectomy and gingivoplasty operations. Clinical Relevance: Platelet concentrates such as i-PRF accelerate wound healing and contribute to the patient’s comfort and quality of life.