Evaluation of Sex Hormones Serum Profile in Male Patients with Behcet’s Disease

Abstract

Abstract Objectives: This cross-sectional study has been done on people with Behcet`s disease referred to Shahid Motahri Clinic and Shiraz Dental Faculty during 2020. Materials and Method: Twenty five men with new confirmed Behcet's disease and twenty healthy men were enrolled in the study. The serum level of LH, FSH, estradiol, progesterone, testosterone, Prolactin, DHEA were evaluated in the Motahari laboratory. Data were analyzed by SPSS version 18. Kolmogrov Smirnov, student T-test, Kruskal Wallis, Chi-square, and one-way ANOVA were used for analysing this study. Results: The mean age of patients in group of patients with Behcet’s disease and healthy controls were 38.55 ± 7.59 and 39.68 ± 9.78 years old respectively. The mean serum level of FSH, LH, and prolactin was significantly higher in Behcet’s patients, while the DHEA mean serum level was higher in healthy controls (p.value < 0.05). The mean value of sex hormones serum level in each group of patients with Behcet’s disease and healthy controls were not different between different age ranges of participants (p.value > 0.05). In Behcet patients, the FSH mean value had a more significant abnormal range, while DHEA mean value had a more significant abnormal range in healthy controls. Conclusion: There is some significant sexual hormonal imbalance in Behcet patients. DHEA deficiency and prolactin increment were reported noticeable for Behcet disease patients. Clinical relevance: Results of this study indicate sexual hormonal imbalance as a predisposing factor and also daigostic factor of behcet disease.