EIF4A3-regulated circGNAI2 inhibits the progression of triple-negative breast cancer by circGNAI2-miR-454-3p-VGLL4 axis

Abstract

Abstract Triple-negative breast cancer (TNBC) is a particularly aggressive subtype of breast cancer (BC) with high invasiveness, high rate of recurrence and metastasis, and poor prognosis. In this study, we demonstrated that circGNAI2 was lower expressed in TNBC tissues and cell lines. CircGNAI2 suppressed the proliferation and migration abilities of TNBC cells in vivo and in vitro. Of note, circGNAI2 can upregulate VGLL4 and inhibit the phosphorylation of STAT3 via sponging miR-454-3p. Moreover, circGNAI2 was downregulated by EIF4A3. Taken together, EIF4A3-regulated circGNAI2 could inhibit TNBC progression by regulating circGNAI2-miR-454-3p-VGLL4 axis and STAT3 signaling pathway, providing pivotal potential therapeutic targets for the treatment of TNBC.