Green pathway for the Construction of Aryl-1,8-Naphthyridine-Thiazole Scaffolds And In Vitro-Antimicrobial Evaluation, DNA-Binding Interactions, Viscosity Measurements, Molecular modeling Studies And ADME Properties
Author:
Sonyanaik Banoth1, Ravi Dharavath2, kishore Kamal1, Shyam Perugu3, Sakram Boda4
Affiliation:
1. Indian Institute of Technology 2. Sree Chitra Tirunal Institute for Medical Sciences & Technology 3. National Institute of Technology 4. Osmania University
Abstract
Abstract
Environmentally friendly research can be bringing cost-effective technology it is essential and desirable in the current state-of-the-art research. Eco-friendly green synthesis of substituted aryl-1,8-naphthyridine-thiazole-4-carboxamide derivatives and evaluation of their biological studies antibacterial and antifungal activity of all the synthesized compounds demonstrated remarkable in-vitro microbial activity as well as DNA binding studies Viscosity Measurements by electronic absorption spectroscopy. The intrinsic binding constants (Kb) values of (5a-f) molecules with Ct-DNA obtained from UV-Vis spectroscopy. Molecular docking studies results and ADME properties were well complemented to the DNA-binding intercalative studies.
Publisher
Research Square Platform LLC
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