ZWINT is a cancer prognosis and immune infiltration-related biomarker from pan-cancer analysis

Abstract

Abstract ZWINT plays an important role in regulating the mitotic checkpoint and cell cycle, and is closely associated with tumor proliferation and migration. Recent studies have shown that high ZWINT expression is associated with poor prognosis in patients with lung adenocarcinoma(LUAD) and Glioblastoma (GBM). Previous analyses of ZWINT were limited to a certain type of cancer, but there has not been a systematic pan-cancer study of ZWINT. We used the TCGA (The Cancer Genome Atlas) project and GTEx data (Genotype-Tissue Expression) to analyze ZWINT expression levels and the correlation with cancer survival prognosis. To understand the underlying biological mechanisms of ZWINT and its relevance to immune infiltration, we systematically analyzed ZWINT-associated genetic alterations, immune infiltration and gene enrichment analysis with different bioinformatics methods. Our study showed that ZWINT mRNA expression was elevated in most human tumors and was significantly increased in the early stages of cancer compared to ZWINT expression in normal tissues.ZWINT high expression is significantly correlated with poor prognosis in most tumors. ZWINT is extensively involved in immune infiltration of tumors. Single cell sequencing data showed that ZWINT was significantly associated with cell cycle, DNA repair, DNA damage, and proliferation. Thus, ZWINT expression correlates with prognosis and immune infiltration in tumor patients. ZWINT may be a potential biomarker for prognosis and an important target for tumor immunotherapy.