Abstract
Objective
To investigate the effect of postoperative intraperitoneal hyperthermic perfusion (IPHP) combined with nutritional support on disease control and survival in patients with locally advanced colorectal cancer (CRC).
Methods
From August 2019 to August 2020, we arbitrarily divided 80 patients with locally advanced CRC into two groups. Each group contained 40 cases. In the control group, the patients were given simple nutritional support after operation, and in the observation group, the patients were cured with intraperitoneal thermal perfusion combined with nutritional support based on the control group. The clinical efficacy was observed. And the recurrence rate, metastasis rate, survival rate, serum thymidine kinase 1 (TK1), cyclooxygenase-2 (COX-2), soluble intercellular adhesion molecule-1 (ICAM-1) levels and life quality scores were compared before and after treatment.
Results
In the observation group, the objective remission rate (ORR) was 80.00%, and the disease control rate (DCR) was 97.50%. In the control group, the ORR was 57.50% and the DCR was 77.50%. There was a remarkable increase in ORR and DCR in the observation group (P < 0.05). Comparatively to the control group (35.00% and 40.00%), the observation group had the lower recurrence and metastasis rates (12.50% and 17.50%, respectively). As compared to the control group (55.00%), the observation group's survival rate was remarkably higher (77.50%) and its survival time was remarkably longer (77.50%). The serum levels of TKI, COX-2 and soluble ICAM-1 were remarkably lessened, and the serum levels in the observation group were lower (P < 0.05). After treatment, the scores of social, physical, role and cognitive functions of patients were remarkably elevated. In the control and observation groups, the incidence of adverse reactions was 27.50% and 5.00% respectively.
Conclusion
IPHP plus with nutritional support is effective in postoperative patients with locally advanced CRC, which can successfully enhance the life quality, reduce the rate of recurrence, prolong the survival time. The treatment approach has been highly safe, which may be relevant to the remarkable reduction of serum TK1, COX-2 and solution ICAM-1 levels.