Affiliation:
1. Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University
Abstract
Abstract
Background
The common infections agents causing meningitis in patients with human immunodeficiency virus (HIV) include Cryptococcus neoformans and Treponema pallidum. Furthermore, there is an elevated risk of meningitis in patients with HIV concomitantly infected with SARS-CoV-2.
Case presentation:
A 38-year-old male presented with headache and dizziness. After hospitalization, polymerase chain reaction test for SARS-CoV-2 in nasopharyngeal swab was positive, and lumbar puncture revealed neurosyphilis with concomitant cryptococcal meningitis. He underwent Paxlovid, penicillin, antifungal and antiretroviral treatment. The patient had no other neurological symptoms and was stable during the 6-month follow-up period.
Conclusions
During the COVID-19 pandemic, patients with HIV, particularly those not underwent antiretroviral therapy, are at higher risk for severe infections, including central nervous system complications, due to their compromised immune systems.
Publisher
Research Square Platform LLC
Reference18 articles.
1. Cryptococcal Meningitis Diagnostics and Screening in the Era of Point-of-Care Laboratory Testing;Rajasingham R;J Clin Microbiol Jan,2019
2. Neurosyphilis in patients with HIV;Hobbs E;Practical Neurol Jun,2018
3. Impact of the COVID-19 pandemic on HIV care in Guatemala;Medina N;Int J Infect diseases: IJID : official publication Int Soc Infect Dis Jul,2021
4. COVID-19-associated Cryptococcus infection (CACI): a review of literature and clinical pearls;Regalla D;Infect Aug,2022
5. COVID-19-associated opportunistic infections: a snapshot on the current reports;Abdoli A;Clin experimental Med Aug,2022