Correlation Analysis of Blood Lipid Level and Thyroid Tumors

Abstract

Abstract Background: The level of blood lipids has been found to reflect the occurrence and development of tumors to a certain extent. This article explores the correlation between blood lipid levels and thyroid tumors. Methods: A total of 915 patients with thyroid tumors were enrolled in this study and divided into two groups according to the benign and malignant tumors. The total cholesterol (TCHO), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), lipoprotein (a) and other detection indicators before starting treatment were recorded. The comparison between the two groups were evaluated by Mann-Whitney test and Chi-square test. The relationship between the blood lipid level and thyroid tumors were assessed by Spearman correlation analysis , dose-effect analysis and logistic regression methods. Results: Serum TCHO (median 4.85 vs 5,14, p=0.001), HDL-C (median 1.37 vs 1.48, p=0.001), LDL-C (median 2.50 vs 2.68, p=0.006) and lipoprotein (a) (median 111 vs 133, p=0.023) levels of patients with malignant thyroid tumors were significantly lower than those of patients with benign thyroid tumors. The logistic regression models showed that the OR value of HDL-C was 0.493(0.272,0.894), and the P value was 0.02. This suggests that HDL-C is a protective factor. In addition, HDL-C was negatively correlated with lymph node metastasis(p=0.005) and the maximum tumor diameter(p=0.024). Conclusion: Serum lipid level is correlated with the occurrence and development of thyroid tumors to a certain extent, and the level of HDL-C is a protective factor for thyroid tumors.