Causal relationships between rhinosiusitis and gastroesophageal reflux disease: a bidirectional two-sample Mendelian randomization study

Author:

Chen Fuhai1,Zhang Jin1,Xie Jing1,Fu Xiao1

Affiliation:

1. Department of Otolaryngology-Head and Neck Surgery, Affiliated Hangzhou First People’s Hospital, School of Medicine, Westlake University, Hangzhou, Zhejiang

Abstract

Abstract Background Gastroesophageal reflux disease (GERD) is associated with acute and chronic rhinosinusitis (ARS/CRS), although the causal relationship between them is not clear. Methods We conducted a bidirectional two-sample Mendelian randomized study to investigate the causal effects between GERD and rhinosinusitis (RS). The data for GERD and RS were obtained from large sample size genome-wide association studies (GWAS). Single-nucleotide polymorphisms (SNPs) associated with each exposure were considered instrumental variables in this study. We conducted a causal effect analysis using the inverse-variance weighted (IVW),Weighted median,MR Egger,Simple mode and Weighted mode methods. The inverse-variance weighted and MR - Egger methods were used for the heterogeneity analysis. The MR - Egger model method was adopted for Pleiotropic effects. Results MR analysis showed that GERD had a statistically significant causal effect on ARS (IVW, OR = 1.324, 95% CI 1.177-1.490, p <0.001) and CRS (IVW, OR = 1.365, 95% CI 1.185-1.572, p <0.001).MR analysis showed that CRS had a statistically significant causal effect on GERD (IVW, OR = 1.033, 95% CI 1.009-1.056, p =0.006). However, the MR-Egger model revealed the evidence of horizontal pleiotropy for the causal effect of CRS on GERD (Egger-intercept=0.007, p=0.032). In addition,we did not observe a causal effect of ARS on GERD (IVW, OR = 1.019, 95% CI 0.986-1.053, p=0.269). Conclusions We confirmed the causal effect of GRED on RS, while no causal effect of RS on GERD was found. These studies are expected to provide high-quality causal evidence for the pathogenesis of RS and GERD, and additional ideas for their primary prevention and treatment.

Publisher

Research Square Platform LLC

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