Affiliation:
1. Shanxi Eye Hospital
2. Fujian Medical University
Abstract
Abstract
Introduction
To identify gut microbiota susceptible to age-related macular degeneration (AMD) development, a Mendelian Randomization (MR) design was employed to systematically screen the gut microbiome for the potential risk of AMD.
Methods
Instrumental variables of 196 gut microbiota were obtained from a genome-wide association study (GWAS) of the MiBioGen consortium. A Mendelian randomization study was conducted to estimate their effects on AMD risk from R8 FinnGen GWAS (7582 AMD cases and 318039 controls). Inverse variance weighted (IVW) is the primary method to analyze causality, and MR results are verified by several sensitivity analyses.
Results
IVW results confirmed that Genus-Faecalibacterium (P = 7.56×10 − 4) was correlated with the risk of AMD. Genus-Candidatus_Soleaferrea (P = 2.05×10 − 3) was a protective factor for AMD. Heterogeneity (P > 0.05) and pleiotropy (P > 0.05) analysis confirmed the robustness of MR results.
Conclusion
We confirmed a potential causal relationship between some gut microbiota taxa and AMD, highlighting the association of the "gut-eye" axis and offering new insights into the gut microbiota-mediated mechanism of AMD.
Publisher
Research Square Platform LLC