FusionPDB: a knowledgebase of human Fusion Proteins

Abstract

Abstract Tumorigenic functions due to the formation of fusion genes were targeted for cancer therapeutics (i.e., kinase inhibitors). However, many fusion proteins are still awaiting being targeted for therapeutics in diverse cellular working mechanisms. Due to the lack of whole fusion protein sequences and whole 3D structures of the fusion proteins, it was hard to develop novel therapeutic approaches. To fill these critical gaps, we developed a new computational pipeline and a resource of human fusion proteins named FusionPDB, available at https://compbio.uth.edu/FusionPDB. FusionPDB provides ~ 43K fusion protein sequences (of 14.7K in-frame fusion genes, Level 1), 2300 + 1267 fusion protein 3D structures (of 2300 recurrent + 266 manually curated in-frame fusion genes, Level 2), and virtual screening results of 1267 fusion proteins (of 266 manually curated in-frame fusion genes, Level 3). FusionPDB is the only resource providing whole 3D structures of fusion proteins and comprehensive knowledge of human fusion proteins. It will be regularly updated until covering all human fusion proteins in the future.