A System for Synthesizing Resveratrol Cocrystals Using Cocrystallization Techniques to Improve the Bio Availability of Resveratrol

Abstract

Abstract Sciatica, a debilitating condition arising from sciatic nerve pathology, presents challenges in its management due to its associated symptoms like radiating pain, muscle weakness, and paraesthesia. Current treatments methods often involve conservative approaches, including exercise, manual therapy, and pain management. However, there remains a need for more effective interventions that can alleviate symptoms and improve the overall quality of life for individuals suffering from this condition.Chronic Constriction Injury nerve pain induced rats received vehicle, resveratrol (50mg/kg) alone and with optimized cocrystal technology developed cocrystals of resveratrol (50 mg/kg) orally for 14 days. Thermal allodynia, cold allodynia and mechanical hyperalgesia tests performed to all animals. Blood and nerve tissues were taken for further studies. In chronic constriction injury group significantly damaged the nerve cells, increased oxidative stress and declined reduced glutathione levels observed. Resveratrol reduced these effects, but much improved attenuation of sciatic pain reversal with cellular damage was resulted with cocrystals of resveratrol. The bioavailability increased by 3.73 folds, Cmax increased from 93.50 ± 11.29 to 349.00 ± 29.65ng/mL and AUC increased from 913.02 ± 79.09 to 2451.25 ± 569.65ng/ml/h with cocrystals of resveratrol a much better than resveratrol. The experiment showed promising results, wherein it is found out that the synthesized resveratrol cocrystals exhibits remarkable efficacy in mitigating sciatic pain induced by chronic constriction injury (CCI), exhibiting potent antioxidant and anti-inflammatory properties. The optimized development of resveratrol cocrystals with suitable conformers will be helpful in new drug development in the pain therapeutics with improved pharmacokinetic and pharmacodynamics.